منابع مشابه
Stem cells and colorectal carcinogenesis
Colorectal cancer represents an important cause of mortality and morbidity. Unfortunately, the physiopathology is still under study. There are theories about carcinogenesis and it is known that not only a single factor is responsible for the development of a tumor, but several conditions. Stem cells are a promising target for the treatment of colorectal cancer, along with the environment that h...
متن کاملMolecular Mechanisms of Colorectal Carcinogenesis
K.M. Haigis (ed.), Molecular Pathogenesis of Colorectal Cancer, DOI 10.1007/978-1-4614-8412-7_2, © Springer Science+Business Media New York 2013 Abstract Colorectal cancer (CRC) presents in three major forms: inherited, sporadic, and familial. Although the mechanisms underlying familial CRC are poorly understood, a large body of evidence suggests that inherited and sporadic CRC are caused by se...
متن کاملThe dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis
The beginnings of the first animal model appreciated for its macroscopic and histological similarity to human colorectal carcinoma (CRC) extend to 1963, when Laqueur discovered that rats fed cycasin, a plant product, developed intestinal cancer. The active substance was identified and soon a similar compound, methylazoxymethanol acetate (MAMA) was synthesized that was more effective than the na...
متن کاملRole of bile acids in colorectal carcinogenesis.
Dietary factors are considered important environmental risk determinants for colorectal cancer development. Epidemiological studies have shown that a high fat (or meat) intake is associated positively and a high starch, fibre (non-starch polysaccharide), vegetable and fruit intake negatively with colorectal cancer incidence. One mechanism by which these effects are possibly exerted is through t...
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Colorectal cancer is one of the most common malignancies and is the second-leading cause of cancer-related death world-wide, which is linked to genetic mutations, epigenetic alterations, and oncogenic signaling activation. MicroRNAs, one of the categories of epigenetics, have been demonstrated significant roles in carcinogenesis and progression through regulating of oncogenic signaling pathways...
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ژورنال
عنوان ژورنال: FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
سال: 2001
ISSN: 0016-2590,2185-4610
DOI: 10.5387/fms.47.1